Cholesterol found in seafood and other foods such as eggs has very little effect on blood cholesterol in most people. Saturated fats and trans fatty acids are the two most important fats that raise blood cholesterol, not cholesterol in your food. Saturated fats are usually found in meat, the skin on poultry and full-fat dairy products like whole milk and cheese. They are the one type of fat responsible for raising total blood cholesterol levels because they raise LDL (“bad”) cholesterol and triglyceride levels. Trans fat is the other type of fat mainly responsible for raising total and LDL cholesterol levels and also for lowering the “good” fat in our blood called HDL cholesterol. Trans fat is commonly found in packaged, processed snack foods, deep-fried foods or firm, stick-type margarine containing partially hydrogenated vegetable oil.

Additional Resources:

http://edis.ifas.ufl.edu/pdffiles/HE/HE69500.pdf
http://www.americanheart.org/presenter.jhtml?identifier=3046103
http://www.americanheart.org/presenter.jhtml?identifier=1516