Major leaks can be found around joints at ductwork connections, around the air handler, and near vents. Look for holes, tears, and loose joints.
Every unsealed joint is likely a small leak—even if a gap is not visible. Make sure registers and vents are firmly attached. If your home has a mechanical closet, it should also be properly sealed to prevent negative return side air leakage. The return chamber should be kept free of debris.
Source: Wendell A. Porter, Hyun-Jeong Lee, and Kathleen C. Ruppert, The Duct System, UF/IFAS FCS3263, 2008.
Additional Resources
UF IFAS Energy Efficient Homes: The Duct System - http://edis.ifas.ufl.edu/FY1024
Florida Building Code - http://www.floridabuilding.org
U.S. Department of Energy – Better Duct Systems for Home Heating and Cooling - http://www.nrel.gov/docs/fy05osti/30506.pdf
U.S. Department of Energy – Improving the Efficiency of Your Duct System - http://apps1.eere.energy.gov/buildings/publications/pdfs/building_america/27630.pdf
U.S. Department of Energy – Minimizing Energy Losses in Ducts – http://www.energysavers.gov/your_home/space_heating_cooling/index.cfm/mytopic=12730
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